Obesity increases the incidence and mortality from some types of cancer, but it remained uncertain whether intentional weight loss can decrease this risk.
In a retrospective cohort study of 30 318 patients, bariatric surgery was significantly associated with a lower risk of obesity-associated cancer and cancer-related mortality. [Aminian A, Wilson R, Al-Kurd A et al. Association of Bariatric Surgery with Cancer Risk and Mortality in Adults with Obesity. JAMA. Published online June 3, 2022. doi:10.1001/jama.2022.9009]
Among adults with obesity, bariatric surgery compared with no surgery was associated with a significantly lower incidence of obesity-associated cancer and cancer-related mortality. This gives one more important benefit of bariatric surgery, in addition to the improvement of metabolic syndrome, type 2 diabetes, and reduction of cardiovascular morbidity.
Dr. Steven Nissen and colleagues compared the impact of various types of bariatric surgery on almost 2,300 people to the usual medical care on more than 11,000 obese patients with similar symptoms treated between 1998 and 2017 at the Cleveland Clinic.
Those having bariatric surgery lost more weight and had fewer heart attacks, fewer strokes, a lower incidence of kidney and heart failure, a lower incidence of atrial fibrillation, lower blood sugar levels, and experienced a 41% lower over all morbidity during the study. Additionally, those who had surgery used fewer medications for diabetes and other conditions.
The researchers concluded that many of the deleterious effects
of obesity are potentially reversible.
Most obese teens remain obese as adults, and adults who were obese as teens are unhealthier than those who become obese later in life.
A new study presented at the Combating Childhood Obesity Conference in Houston (Weight Loss and Health Status 3 Years after Bariatric Surgery in Adolescents. Inge TH, Courcoulas AP, Jenkins TM, et al. N Engl J Med 2016; 374:113-123) suggests that teens may benefit more from early surgery than adults.
The researchers compared results from two studies of gastric bypass surgery in 161 teens and 396 adults who had been obese since they were teens. Three years after their operations, both groups had lost between 26% to 29% of their weigh and Diabetes went into remission in 86% of teens and 53% of adults diagnosed with the disease before surgery. High blood pressure was also normalized in 68% of teens and 41% of adults.
Although a 2% mortality accompanied surgery in both groups, two of the teens died from drug overdoses, suggesting substance abuse and self harm may accompany teen obesity.
The researchers documented the durability of clinically meaningful weight loss and metabolic improvements and weight-related quality of life among adolescents who underwent gastric bypass surgery or sleeve gastrectomy. The benefits of these current bariatric surgical alternatives must be viewed in the context of the risks of nutritional deficiencies and the possibility that future surgical procedures will be needed in some patients.
It is this author’s hope that Endoscopic Visceral Lipectomy, which does not expose the patient to the nutritional and surgical risks inherent in bypass surgery or sleeve gastrectomy, may prove equally effective and a safer minimally invasive intervention for this younger population (Uncoiling the Tightening Obesity Spiral. Cucin RL Clin Res Diab Endocrinol:1(2):1-5 (2018)).