Obese Mothers Give Their Babies a Bad Start

Researchers have reported that babies of mothers who have unhealthy obesity, i.e. obesity along with one or more metabolic comorbidities, are born with greater levels of adiposity than the offspring of women with obesity without such comorbidities.  [A role for the early pregnancy maternal milieu in the intergenerational transmission of obesity. [Flanagan EW, Most J, Altazan AD, Boyle KE, Redman LM  11/4/21 doi.org/10.1002/oby.23283]. Unhealthy metabolic risk factors in addition to obesity included a bad lipid profile or an elevated blood sugar.

As obesity rates continue to increase among the adult population, the rates of obesity will continue to increase among our children, resulting in a tightening spiral of increasing obesity among our youth. [Uncoiling the Tightening Obesity Spiral.  Cucin RL  Clin Res Diab Endocrinol:1(2):1-5 (2018)]

 

Obesity-Related Cancer Deaths are on the Rise and Trends Parallel Those Observed for Heart Disease.

While Overall mortality rates for cancer continue to decline in the U.S., since 2011, that decline has slowed for obesity-associated cancers.  The mortality trends for obesity-associated cancers mirror those for heart disease,

According to Christy Avery, PhD, of the University of North Carolina at Chapel Hill, and colleagues . “After four decades of decline, annual improvements in heart disease mortality slowed in 2011; this slowing has been associated with the obesity epidemic,”   [Avery CL, Howard AG, Nichols HB, JAMA Open. 2021;4(5):e218356. doi:10.1001/jamanetworkopen.2021.8356].  

The researchers found that trends in obesity-associated cancer mortality and heart disease mortality showed slowing improvements that emerged in the second decade of the 21st century.  The investigators conclude these effects are caused by the ongoing obesity epidemic in which 2 out of 5 Americans are now obese.

 

Cleveland Clinic Study Finds Weight Loss Surgery Decreases Risk of Heart Attack and Stroke

Dr. Steven Nissen and colleagues compared the impact of various types of bariatric surgery on almost 2,300 people to the usual medical care on more than 11,000 obese patients with similar symptoms treated between 1998 and 2017 at the Cleveland Clinic.

Those having bariatric surgery lost more weight and had fewer heart attacks, fewer strokes, a lower incidence of kidney and heart failure, a lower incidence of atrial fibrillation, lower blood sugar levels, and experienced a 41% lower over all morbidity during the study.  Additionally, those who had surgery used fewer medications for diabetes and other conditions.

The researchers concluded that many of the deleterious effects of obesity are potentially reversible.